Sometimes Drugs Cause Aggression

A final issue related to confounding is the effect of psychiatric medications on aggression. In a review of clinical aspects of dangerous behaviour, Menuck (1983) describes a number of iatrogenic or paradoxical drug reactions including:

Tranquilizer-sedatives (e.g. benzodiazepine and barbiturates) may have a disinhibiting effect on affect and behaviour. Paradoxical drug reactions involving violent behaviour have been reported among incarcerated offenders, psychiatric patients, and control group volunteers receiving these drugs.
Drugs that are capable of producing hypomania may elicit aggressive behaviour by arousal of the central nervous system. Aggressive behaviour has been reported among persons treated with imipramine and amitriptyline, phenylzine, prednisone, and bromocriptine.
Neuroleptic drugs sometimes increase aggressivity. This phenomenon has been observed during both low and high dose pharmacotherapy.

Thus any aggression found in psychiatrically disabled people on medication is due to their medication, regardless of any denial by any one person on medication.

What actually has been found is that opioid disorder (addiction to painkillers) reduces aggression, and most people with such disorders are less likely to exhibit aggressive behavior leading to violence. Indeed, IMHO they are the most compliant of substance users.

However, IMHO hypomania caused by medication is no different from substance abuse with regard to increased aggression.

Therefore, non-violent methods of confrontation and intervention are required to reduce aggression, regardless of whether one's substance use is illicit or approved by their doctor.

With regard to behavior, there is no difference between medication and substance abuse.