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20080126

The Long Search for an OTC Anti-Depressant

Reference: http://en.wikipedia.org/wiki/Chlorphenamine

According to the literature, diphenhydramine is the precursor to Prozac. This product is known as Benadryl. It is a first generation antihistamine, usually administered for allergic conditions such as hay fever, hives and the like.

However, cetirizine (Reactine) and loratadine (Claritin) have less effect on serotonin receptors, being second-generation antihistamines. They still relieve allergic conditions, but with almost no effect unlike Benadryl.

But chlorpheniramine (Chlor-Tripalon) appears to have a similar effect to diphenhydramine, with a faster onset of sedation and reduction of allergic reaction. Indeed, 12 mg of chlorpheniramine has the same effect as 75 mg of diphenhydramine. This suggests that the lower dose form of 4 mg is equivalent to 25 mg of diphenhydramine.

When mixed with high caffeine energy drinks, a near-giddy feeling occurs within the first ten minutes, followed by about 10-12 hours of a comfortable feeling without the mental fogginess that diphenhydramine sometimes brings.

Accompanying chlorpheniramine's effects is the ability to make conversation with strangers without feelings of intruding on another person's private space. The sedation of the product makes it superb in situations where high stress could induce hyperexciteability.

According to the literature, chlorpheniramine is sometimes used to calm patients as a nearly non-addictive alternative to the benzodiazepines.

This product, like diphenhydramine, could become the first OTC anti-depressant. The only side effects are rebound allergic symptoms due to suppression.

*** The observations noted in this entry is not an endorsement of drug abuse. The author takes no responsibility for the actions of other people reading should they decide to try any drug mentioned in it. Thouugh, the author does endorse a "less-is-more" attitude towards drugs i.e. use only enough to give a slight reaction to ingestion but do not combine with other drugs.

2 comments:

Sageb1 said...

This is Day 3 while taking chlorpheniramine, and the sedative effects are more enjoyable than diphenhydramine.

Sageb1 said...

I really don't understand why I like chlorpheniramine versus diphenhydramine.

It could be the risk of anticholinergic psychosis from diphenhydramine which is not in the literature of effects at Erowid for chlorpheniramine.

Yet at the same time there is not the impairment of intellect that diphehydramine sometimes causes.

At the same time this is not a drug to be mixing with the alcohol but its 21-28 hour half-life means that you can use it every other day to give you relief.

Plus, it has less risks to use than pot.